This problem may occur for a number of reasons. Please try the following options to resolve the problem.
Restart your computer.
On a PC, check the Task Manager for a process called emailhelper86.exe. If it is running then select it and hit "end process"
This problem may occur because your library is stored in a read only location. Try moving the file (and the associated data folder) to a new location.
Check you do not have your library stored on a network drive or on a cloud drive, such as iCloud, Dropbox or Google Drive. If it is stored in one of these locations move it to a location on your computer.
Uninstall and reinstall EndNote (note this will not affect the library, but you should make a habit of keeping a back-up copy anyway).
We acknowledge the Australian Aboriginal and Torres Strait Islander peoples as the first inhabitants of the nation and acknowledge Traditional Owners of the lands where our staff and students, live, learn and work.